Transaminase Enzyme and Liver Histological Profile of Mice Administered Extract of Pegagan (Centella asiatica (L.) Urban)

  • B Muchtaromah
  • . Kiptiyah
  • T T Adi
Keywords: pegagan extract, GPT, GOT, liver histology, mice

Abstract

The purpose of this study was to determine whether pegagan caused toxic effects on the liver. This study used completely randomized design with four treatments, ie 125, 200, 275 mg/kg BW and control, each treatment consisting of six replicates. Variables observed were the level of GPT, GOT and histological profile of liver. GPT and GOT levels were analyzed by analysis of single variant of 0.05. Histological picture of the liver include central venous dilation, inflammation, and damage to the structure of liver cells were performed by descriptive evaluation. Pegagan leaf extract did not show significant effect on GPT and GOT level in the liver of mice, whereas the histology results did not reveal any visible damage to liver cells in each dose. Administration of pegagan extract up to dose of 275 mg/kg BW was safe and would not cause damage to the liver cells.

Author Biographies

B Muchtaromah

Department of Biology, Faculty of Science and Technology

University of Islamic State Maulana Malik Ibrahim Malang

Jln. Gajayana 50 Malang, East Java, Indonesia
. Kiptiyah

Department of Biology, Faculty of Science and Technology

University of Islamic State Maulana Malik Ibrahim Malang

Jln. Gajayana 50 Malang, East Java, Indonesia
T T Adi

Department of Biology, Faculty of Science and Technology

University of Islamic State Maulana Malik Ibrahim Malang

Jln. Gajayana 50 Malang, East Java, Indonesia
Published
2011-09-09